Biochemical Evidence of Metabolic Bone Disease in Women
Following Roux-Y Gastric Bypass for Morbid Obesity

Ott MT, Fanti P, Malluche HH, Ryo UY, Whaley FS, Strodel WE, Colacchi TA.
Colon and Rectal Clinic, University of Texas Medical Center, Houston, TX

Obes Surg 1992 Nov;2(4):341-348

Twenty-six female patients were recalled for examination 10 years after a Roux-Y gastric bypass (RGB) procedure for morbid obesity, to determine whether there was biochemical and/or bone densitometry evidence of metabolic bone disease. These patients were compared with seven control patients who had achieved weight loss by dietary restriction. The serum calcium (4.3 +/- 0.03 vs 4.6 +/- 0.06 mEq/l; p = 0.002) was decreased in the RGB group. Both the serum alkaline phosphatase level (121.0 +/- 7.6 vs 87.3 +/- 8.3 U/I; p = 0.018) and the serum osteocalcin (12.6 +/- 1.2 vs 9.5 +/- 1.9 ?g/ml; p = 0.078) level increased in the RGB group.

The 1,25(OH) vitamin D level (50.5 +/- 2.5 vs 40.5 +/- 4.9 pg/ml; p = 0.152) was similar for both groups; the 25(OH) vitamin D level (24.3 +/- 1.6 vs 35.9 +/- 3.4 ng/ml; p = 0.008) was decreased in the RGB group as compared with the control group. Bone mineral density was elevated in three of the lumbar measurement sites, and marginally decreased (0.90 +/- 0.02 g/cm(2) vs 1.03 +/- 0.06 g/cm(2); p = 0.067) in the femoral neck of the RGB group compared with the controls. This biochemical pattern suggests the development of metabolic bone disease following the RGB.

PMID: 10765194 [PubMed - as supplied by publisher]

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